About the Endocannabinoid System in the Human Body


Source: US National Institutes of Health

“In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs. More importantly, modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few.”

Open Study

Endocannabinoids and Phytocannabinoids

Endocannabinoids created within the human regulate the correct physiological functions of the body called homeostasis. Phytocannabinoids found in Cannabis plants are a perfect supplement to the body’s own endocannabinoids and thus are helping to balance and stabilize the physiological functions.

diCBDium – our 100% natural dietary supplement – contains, among other beneficial substances like minerals, vitamins, flavonoids terpenes and others, various cannabinoids and therefore is suitable as a supplement for endocannabinoids within the human endocannabinoid system.

Studies According to the Implied Benefits of CBD

Guindon, J., Hohmann, A. G.: The Endocannabinoid System and Pain
CNS & Neurological Disorders – Drug Targets, Vol. 8, No 6, December 2009, pp. 403-421(19)

Lone T.A., Lone R.A.: Extraction of cannabinoids from cannabis sativa
Universal Journal of Medicine and Dentistry, Vol. 1(4), pp. 051-055, April, 2012

Jones, N. A., Hill A. J., Smith I., Bevan S. A., Williams C. M., Whalley B. J., and Stephens G. J.: Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo
Journal of Pharmacology and Experimental Therapeutics, 2010 Feb; 332(2): 569–577

Rock E.M., Bolognin D., Limebeer C.L., Anavi-Goffer S., Fletcher P.J., Mechoulam R., Pertwee R.G., and Parker L.A.: Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
British Journal of Pharmacology, 2012 Apr; 165(8): 2620–2634

Hayakawa K., Mishima K., Irie K., Mishima S., Fujioka M., Orito K., Egashira N., Katsurabayashi S., Takasaki K., Iwasaki K., and Fujiwara M.: Cannabidiol prevents a post-ischemic injury progressively induced by cerebral ischemia via a high-mobility group box1-inhibiting mechanism
Neuropharmacology, Volume 55, Issue 8, December 2008, pp. 1280-1286

Booz G.W.: Cannabidiol as an Emergent Therapeutic Strategy for Lessening the Impact of Inflammation on Oxidative Stress
Free Radical Biology and Medicine, Volume 51, Issue 5, 1 September 2011, pp. 1054-1061

Iuvone T., Esposito G., Esposito R., Santamaria R., Di Rosa M., and Izzo A.A.: Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on β-amyloid-induced toxicity in PC12 cells
Journal of Neurochemistry, Volume 89, Issue 1, February 2004, pp. 134–141

Fine P.G. and Rosenfeld M.J.: The Endocannabinoid System, Cannabinoids, and Pain
Rambam Maimonides Medical Journal, 2013 Oct; 4(4): e0022

Vaccani A., Massi P., Colombo A., Rubino T., and Parolaro D.: Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
British Journal of Pharmacology, 2005 Apr; 144(8): 1032–1036

Mounessa J.S., Siegel J.A., Dunnick C.A., Dellavalle R.P.: The role of cannabinoids in dermatology
Journal of the American Academy of Dermatology, Volume 77, Issue 1, July 2017, pp 188-190

Zuardi A.W., Crippa J.A., Hallak J.E., Bhattacharyya S., Atakan Z., Martin-Santos R., McGuire P.K., and Guimarães F.S.: A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation
Current Pharmaceutical Design, 2012; 18(32): 5131-40

Hussain S.A., Zhou R., Jacobson C., Weng J., Cheng E., Lay J., Hung P., Lerner J.T., and Sankar R.: Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox–Gastaut syndrome
Epilepsy & Behavior, Volume 47, June 2015, pp. 138-141

Napimoga M.H., Benatti B.B., Limac F.O., Alvesa P.M., Camposc C.S., Pena-dos-Santos D.R., Severino F.P., Cunha F.Q., Guimarães F.S.: Cannabidiol decreases bone resorption by inhibiting RANK/RANKL expression and pro-inflammatory cytokines during experimental periodontitis in rats
International Immunopharmacology, Volume 9, Issue 2, February 2009, pp. 216-222

X.-H. Lin, B. Yuece, Y.-Y. Li, Y.-J. Feng, J.-Y. Feng, L.-Y. Yu, K. Li, Y.-N. Li, M. Storr: A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents
Neurogastroenterology & Motility, Volume 23, Issue 9, September 2011, pp. 862–e342

Iuvone T., Esposito G., De Filippis D., Scuderi C., and Steardo Luca: Cannabidiol: A Promising Drug for Neurodegenerative Disorders?
CNS Neuroscience & Therapeutics, Volume 15, Issue 1, Spring 2009, pp. 65–75

Studies According to the Diagnosis

Cannabis kills tumor cells

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1576089
http://www.ncbi.nlm.nih.gov/pubmed/20090845
http://www.ncbi.nlm.nih.gov/pubmed/616322
http://www.ncbi.nlm.nih.gov/pubmed/14640910
http://www.ncbi.nlm.nih.gov/pubmed/19480992
http://www.ncbi.nlm.nih.gov/pubmed/15275820
http://www.ncbi.nlm.nih.gov/pubmed/15638794
http://www.ncbi.nlm.nih.gov/pubmed/16818650
http://www.ncbi.nlm.nih.gov/pubmed/17952650
http://www.ncbi.nlm.nih.gov/pubmed/20307616
http://www.ncbi.nlm.nih.gov/pubmed/16616335
http://www.ncbi.nlm.nih.gov/pubmed/16624285
http://www.ncbi.nlm.nih.gov/pubmed/10700234
http://www.ncbi.nlm.nih.gov/pubmed/17675107
http://www.ncbi.nlm.nih.gov/pubmed/14617682
http://www.ncbi.nlm.nih.gov/pubmed/17342320
http://www.ncbi.nlm.nih.gov/pubmed/16893424
http://www.ncbi.nlm.nih.gov/pubmed/15026328

Lung cancer

http://www.ncbi.nlm.nih.gov/pubmed/25069049
http://www.ncbi.nlm.nih.gov/pubmed/22198381?dopt=Abstract
http://www.ncbi.nlm.nih.gov/pubmed/21097714?dopt=Abstract

Breast cancer

http://www.ncbi.nlm.nih.gov/pubmed/18454173
http://www.ncbi.nlm.nih.gov/pubmed/16728591
http://www.ncbi.nlm.nih.gov/pubmed/9653194

Cannabis partially/fully induced cancer cell death

http://www.ncbi.nlm.nih.gov/pubmed/12130702
http://www.ncbi.nlm.nih.gov/pubmed/19457575
http://www.ncbi.nlm.nih.gov/pubmed/18615640
http://www.ncbi.nlm.nih.gov/pubmed/17931597
http://www.ncbi.nlm.nih.gov/pubmed/18438336
http://www.ncbi.nlm.nih.gov/pubmed/19916793
http://www.ncbi.nlm.nih.gov/pubmed/18387516
http://www.ncbi.nlm.nih.gov/pubmed/15453094
http://www.ncbi.nlm.nih.gov/pubmed/19229996
http://www.ncbi.nlm.nih.gov/pubmed/9771884
http://www.ncbi.nlm.nih.gov/pubmed/18339876
http://www.ncbi.nlm.nih.gov/pubmed/12133838
http://www.ncbi.nlm.nih.gov/pubmed/16596790
http://www.ncbi.nlm.nih.gov/pubmed/11269508
http://www.ncbi.nlm.nih.gov/pubmed/15958274
http://www.ncbi.nlm.nih.gov/pubmed/19425170
http://www.ncbi.nlm.nih.gov/pubmed/17202146
http://www.ncbi.nlm.nih.gov/pubmed/11903061
http://www.ncbi.nlm.nih.gov/pubmed/15451022
http://www.ncbi.nlm.nih.gov/pubmed/20336665
http://www.ncbi.nlm.nih.gov/pubmed/19394652
http://www.ncbi.nlm.nih.gov/pubmed/11106791
http://www.ncbi.nlm.nih.gov/pubmed/19189659
http://www.ncbi.nlm.nih.gov/pubmed/16500647
http://www.ncbi.nlm.nih.gov/pubmed/19539619
http://www.ncbi.nlm.nih.gov/pubmed/19059457
http://www.ncbi.nlm.nih.gov/pubmed/16909207
http://www.ncbi.nlm.nih.gov/pubmed/18088200
http://www.ncbi.nlm.nih.gov/pubmed/10913156
http://www.ncbi.nlm.nih.gov/pubmed/18354058
http://www.ncbi.nlm.nih.gov/pubmed/19189054
http://www.ncbi.nlm.nih.gov/pubmed/17934890
http://www.ncbi.nlm.nih.gov/pubmed/16571653
http://www.ncbi.nlm.nih.gov/pubmed/19889794
http://www.ncbi.nlm.nih.gov/pubmed/15361550

Cannabis kills cancer cells

http://www.ncbi.nlm.nih.gov/pubmed/16818634
http://www.ncbi.nlm.nih.gov/pubmed/12648025
http://www.ncbi.nlm.nih.gov/pubmed/17952650
http://www.ncbi.nlm.nih.gov/pubmed/16835997

Cannabinoids in health and disease

http://www.ncbi.nlm.nih.gov/pubmed/18286801

Cannabis cancer cures (general)

http://www.ncbi.nlm.nih.gov/pubmed/12514108
http://www.ncbi.nlm.nih.gov/pubmed/15313899
http://www.ncbi.nlm.nih.gov/pubmed/20053780
http://www.ncbi.nlm.nih.gov/pubmed/18199524
http://www.ncbi.nlm.nih.gov/pubmed/19589225
http://www.ncbi.nlm.nih.gov/pubmed/12182964
http://www.ncbi.nlm.nih.gov/pubmed/19442435
http://www.ncbi.nlm.nih.gov/pubmed/12723496
http://www.ncbi.nlm.nih.gov/pubmed/16250836
http://www.ncbi.nlm.nih.gov/pubmed/17237277

Prostate cancer

http://www.ncbi.nlm.nih.gov/pubmed/12746841?dopt=Abstract
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339795/?tool=pubmed
http://www.ncbi.nlm.nih.gov/pubmed/22594963
http://www.ncbi.nlm.nih.gov/pubmed/15753356
http://www.ncbi.nlm.nih.gov/pubmed/10570948
http://www.ncbi.nlm.nih.gov/pubmed/19690545

Brain cancer

http://www.ncbi.nlm.nih.gov/pubmed/11479216

Mouth and throat cancer

http://www.ncbi.nlm.nih.gov/pubmed/20516734

Skin cancer

http://www.ncbi.nlm.nih.gov/pubmed/12511587
http://www.ncbi.nlm.nih.gov/pubmed/19608284

Uterine, testicular, and pancreatic cancers

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4
http://www.ncbi.nlm.nih.gov/pubmed/20925645

Blood cancer

http://www.ncbi.nlm.nih.gov/pubmed/12091357
http://www.ncbi.nlm.nih.gov/pubmed/16908594

Liver cancer

http://www.ncbi.nlm.nih.gov/pubmed/21475304

Cancers of the head and neck

http://ww.ncbi.nlm.nih.gov/pmc/articles/PMC2277494

Cholangiocarcinoma cancer

http://ww.ncbi.nlm.nih.gov/pubmed/19916793
http://www.ncbi.nlm.nih.gov/pubmed/21115947

Leukemia

http://www.ncbi.nlm.nih.gov/pubmed/15454482
http://www.ncbi.nlm.nih.gov/pubmed/16139274
http://www.ncbi.nlm.nih.gov/pubmed/14692532

Translocation-positive rhabdomyosarcoma

http://www.ncbi.nlm.nih.gov/pubmed/19509271

Lymphoma

http://www.ncbi.nlm.nih.gov/pubmed/18546271
http://www.ncbi.nlm.nih.gov/pubmed/16936228
http://www.ncbi.nlm.nih.gov/pubmed/16337199
http://www.ncbi.nlm.nih.gov/pubmed/19609004

Melanoma

http://www.ncbi.nlm.nih.gov/pubmed/17065222

Thyroid carcinoma

http://www.ncbi.nlm.nih.gov/pubmed/18197164

Colon cancer

http://www.ncbi.nlm.nih.gov/pubmed/18938775
http://www.ncbi.nlm.nih.gov/pubmed/19047095

Intestinal inflammation and cancer

http://www.ncbi.nlm.nih.gov/pubmed/19442536