{"id":27566,"date":"2022-04-13T13:20:38","date_gmt":"2022-04-13T11:20:38","guid":{"rendered":"https:\/\/new.cbdium.eu\/?p=27566"},"modified":"2024-07-11T16:32:07","modified_gmt":"2024-07-11T14:32:07","slug":"studie-naznacuji-ze-cbd-muze-pomoci-pri-lecbe-priznaku-covid-19","status":"publish","type":"post","link":"https:\/\/cbdium.eu\/cs\/studie-naznacuji-ze-cbd-muze-pomoci-pri-lecbe-priznaku-covid-19\/","title":{"rendered":"Studie nazna\u010duj\u00ed, \u017ee CBD m\u016f\u017ee pomoci p\u0159i l\u00e9\u010db\u011b p\u0159\u00edznak\u016f COVID-19"},"content":{"rendered":"\n

Rychl\u00e9 \u0161\u00ed\u0159en\u00ed COVID-19 a p\u0159ib\u00fdv\u00e1n\u00ed nov\u00fdch variant zd\u016fraz\u0148uje vzhledem k z\u00e1va\u017enosti situace pot\u0159ebu nov\u00fdch l\u00e9\u010debn\u00fdch postup\u016f. Na z\u00e1klad\u011b <\/em>studie, kterou provedli v\u011bdci z University of Chicago na 85 neo\u010dkovan\u00fdch pacientech s COVID<\/em><\/a>, jsme se dozv\u011bd\u011bli, \u017ee u\u017e\u00edv\u00e1n\u00edm CBD p\u0159i COVID-19 m\u016f\u017eeme potenci\u00e1ln\u011b \u0159e\u0161it p\u0159\u00edznaky tohoto virov\u00e9ho onemocn\u011bn\u00ed a p\u0159\u00edpadn\u011b zlep\u0161it prevenci.<\/em><\/p>\n\n\n\n

Endokanabinoidn\u00ed receptory <\/h2>\n\n\n\n

V t\u011ble m\u00e1me b\u011b\u017en\u011b p\u0159\u00edtomn\u00e9 dva hlavn\u00ed endokanabinoidn\u00ed receptory<\/strong>: CB1 a CB2. Tyto receptory se nach\u00e1zej\u00ed po cel\u00e9m t\u011ble. Endokanabinoidy se na n\u011b v\u00e1\u017eou, aby daly endokanabinoidn\u00edmu syst\u00e9mu sign\u00e1l k \u010dinnosti. Receptory CB1<\/strong> se v\u011bt\u0161inou nach\u00e1zej\u00ed v centr\u00e1ln\u00ed nervov\u00e9 soustav\u011b, tj. i v mozku.<\/p>\n\n\n\n

CB2<\/strong> se nach\u00e1zej\u00ed v t\u011blesn\u00fdch bu\u0148k\u00e1ch, kter\u00e9 kontroluj\u00ed imunitn\u00ed funkci, a v perifern\u00ed nervov\u00e9 soustav\u011b. P\u0159i onemocn\u011bn\u00ed COVID jsou plicn\u00ed receptory v\u00fdznamn\u011b napad\u00e1ny virem. Pak je \u017e\u00e1douc\u00ed pos\u00edlit receptor CB2. Toho m\u016f\u017eeme dos\u00e1hnout pou\u017eit\u00edm CBD p\u0159i onemocn\u011bn\u00ed COVID-19.<\/p>\n\n\n\n

<\/p>\n\n\n\n

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\"CBD<\/figure>\n<\/figure>\n<\/div>\n<\/div>\n\n\n\n

Jak p\u016fsob\u00ed \u017eiv\u00e9 kanabinoidy CBD p\u0159i COVID-19?<\/h2>\n\n\n\n

\u017div\u00e9 kanabinoidy<\/strong> aktivuj\u00ed v organismu receptory CB2, kter\u00e9 aktivn\u011b opravuj\u00ed bu\u0148ky v plic\u00edch a v cel\u00e9m d\u00fdchac\u00edm \u00fastroj\u00ed. N\u00e1sledn\u011b v\u00fdrazn\u011b zvy\u0161uj\u00ed aktivaci p\u0159irozen\u00e9ho imunitn\u00edho a endokrinn\u00edho syst\u00e9mu. Kanabinoidy tak mohou b\u00fdt velmi \u00fa\u010dinn\u00e9 jako prevence, jako antivirotikum v po\u010d\u00e1te\u010dn\u00edch stadi\u00edch infekce a tak\u00e9 jako v\u00fdznamn\u00e1 pomoc p\u0159i rekonvalescenci po onemocn\u011bn\u00ed COVID.<\/p>\n\n\n\n

Mnoho sou\u010dasn\u00fdch studi\u00ed se zab\u00fdv\u00e1 t\u00edm, jak kanabinoidy spolupracuj\u00ed s receptorem CB2 v t\u011ble. Citujeme z nov\u00e9 v\u011bdeck\u00e9 studie proveden\u00e9 na 85 neo\u010dkovan\u00fdch pacientech s COVID<\/a>: <\/p>\n\n\n\n

\u201eKanabidiol (CBD), slou\u010denina produkovan\u00e1 rostlinou konop\u00ed, inhibuje (eliminuje) infekci SARS-CoV-2. CBD a jeho metabolit 7-OH-CBD, nikoli kongenerick\u00e9 kanabinoidy, \u00fa\u010dinn\u011b blokuj\u00ed replikaci SARS-CoV-2 v plicn\u00edch epitelov\u00fdch bu\u0148k\u00e1ch. Kanabinoidy CBD p\u016fsob\u00ed po bun\u011b\u010dn\u00e9 infekci. Inhibuje expresi virov\u00fdch gen\u016f a zvr\u00e1t\u00ed mnoh\u00e9 \u00fa\u010dinky SARS-CoV-2 na transkripci hostitelsk\u00e9ho genu.<\/em>

CBD indukuje expresi interferonu (podporuje produkci interferonov\u00fdch glykoprotein\u016f) a reguluje jeho antivirovou sign\u00e1ln\u00ed dr\u00e1hu. Mno\u017eina lidsk\u00fdch pacient\u016f, kte\u0159\u00ed d\u0159\u00edve u\u017e\u00edvali CBD, m\u011bla v\u00fdrazn\u011b ni\u017e\u0161\u00ed v\u00fdskyt infekce SARSCoV-2 a\u017e o \u0159\u00e1dovou velikost v porovn\u00e1n\u00ed s odpov\u00eddaj\u00edc\u00edmi p\u00e1ry nebo obecnou populac\u00ed. Tato studie zd\u016fraz\u0148uje CBD a jeho aktivn\u00ed metabolit, 7-OH-CBD, jako potenci\u00e1ln\u00ed preventivn\u00ed \u010dinidla a terapeutick\u00e9 l\u00e9\u010dby SARS-CoV-2 v po\u010d\u00e1te\u010dn\u00edch st\u00e1di\u00edch infekce.\u201d

<\/em>Jak ji\u017e v\u00edme, kanabinoidy, jako je kanabidiol (CBD), maj\u00ed n\u011bkolik vlastnost\u00ed, kter\u00e9 mohou b\u00fdt u\u017eite\u010dn\u00e9 p\u0159i l\u00e9\u010db\u011b ur\u010dit\u00fdch zdravotn\u00edch p\u0159\u00edznak\u016f: CBD m\u00e1 protiz\u00e1n\u011btliv\u00e9 vlastnosti, m\u016f\u017ee p\u016fsobit jako relaxant a m\u00e1 schopnost sni\u017eovat bolest a \u00fazkost. Kdy\u017e v t\u011ble dopln\u00edme kanabinoidy, zvyknou si velmi siln\u011b posilovat CB2. Ten je n\u00e1sledn\u011b schopen opravovat bu\u0148ky v plic\u00edch. V tomto p\u0159\u00edpad\u011b samoz\u0159ejm\u011b \u0159et\u011bzov\u00e1 reakce neposiluje pouze tento receptor, ale tak\u00e9 endokrinn\u00ed a imunitn\u00ed syst\u00e9m.<\/p>\n\n\n\n

Co prok\u00e1zalo u\u017e\u00edv\u00e1n\u00ed CBD p\u0159i COVID-19?<\/h2>\n\n\n\n

Nejlep\u0161\u00ed v\u00fdsledky se ve studi\u00edch u\u017e\u00edv\u00e1n\u00ed CBD p\u0159i COVID-19 potvrdily p\u0159i rekonvalescenci, zejm\u00e9na pokud jde o krat\u0161\u00ed dobu zotavov\u00e1n\u00ed, m\u00e9n\u011b v\u00fdrazn\u00e9 p\u0159\u00edznaky a v\u0161eobecn\u00e9 t\u011blesn\u00e9 p\u0159\u00edznaky. Skv\u011bl\u00e9 v\u00fdsledky byly prok\u00e1z\u00e1ny i p\u0159i prevenci a tak\u00e9 u akutn\u00edch stav\u016f.<\/p>\n\n\n\n

\u201eNa\u0161e v\u00fdsledky nazna\u010duj\u00ed, \u017ee CBD m\u016f\u017ee blokovat infekci SARS-CoV-2 v \u010dasn\u00fdch st\u00e1di\u00edch infekce a pod\u00e1v\u00e1n\u00ed CBD je u lid\u00ed spojeno s ni\u017e\u0161\u00edm rizikem infekce SARS-CoV-2. Krom\u011b toho aktivn\u00ed slou\u010deninou u pacient\u016f je pravd\u011bpodobn\u011b 7-OH-CBD, stejn\u00fd metabolit, kter\u00fd se pod\u00edl\u00ed na CBD l\u00e9\u010db\u011b epilepsie. Podstatn\u00e9 sn\u00ed\u017een\u00ed rizika infekce SARS-CoV-2 p\u0159ibli\u017en\u011b o jeden rad u pacient\u016f, kte\u0159\u00ed u\u017e\u00edvali CBD schv\u00e1len\u00e9 FDA (U.S. Food and Drug Administration \u2013 Americk\u00fd \u00fa\u0159ad pro potraviny a l\u00e9\u010diva). Poukazuje na potenci\u00e1ln\u00ed \u00fa\u010dinnost tohoto l\u00e9ku v boji proti infekci SARS-CoV-2. Schopnost CBD inhibovat replikaci MHV (Mouse Hepatitis Virus) zvy\u0161uje mo\u017enost, \u017ee CBD m\u016f\u017ee b\u00fdt \u00fa\u010dinn\u00e9 i proti nov\u00fdm patogenn\u00edm vir\u016fm, kter\u00e9 se objev\u00ed v budoucnosti,\u201d<\/em> studie<\/a> d\u00e1le prav\u00ed v diskusi.<\/p>\n\n\n\n

V ka\u017ed\u00e9m p\u0159\u00edpad\u011b jsou \u010distota CBD a zejm\u00e9na slo\u017een\u00ed materi\u00e1l\u016f ozna\u010den\u00fdch jako CBD nesm\u00edrn\u011b d\u016fle\u017eit\u00e9, zejm\u00e9na ve sv\u011btle zji\u0161t\u011bn\u00ed, kter\u00e1 nazna\u010duj\u00ed, \u017ee jin\u00e9 kanabinoidy, jako je nap\u0159\u00edklad THC, mohou p\u016fsobit proti antivirov\u00e9 \u00fa\u010dinnosti CBD.A\u010dkoli je st\u00e1le zapot\u0159eb\u00ed dal\u0161\u00edch klinick\u00fdch studi\u00ed<\/strong>, aby bylo mo\u017en\u00e9 ur\u010dit optim\u00e1ln\u00ed d\u00e1vku a na\u010dasov\u00e1n\u00ed u\u017e\u00edv\u00e1n\u00ed CBD u pacient\u016f s p\u0159\u00edznaky COVID-19, aktu\u00e1ln\u011b podle v\u011bdc\u016f existuje velmi vysok\u00fd p\u0159edpoklad, \u017ee CBD m\u016f\u017ee pozitivn\u011b p\u0159isp\u011bt k \u0159e\u0161en\u00ed onemocn\u011bn\u00ed souvisej\u00edc\u00edch s COVID-19. Pro jak\u00fdkoli definitivn\u00ed z\u00e1v\u011br o u\u017e\u00edv\u00e1n\u00ed CBD p\u0159i onemocn\u011bn\u00ed COVID-19 je v\u0161ak st\u00e1le pot\u0159ebn\u00e9 prov\u00e9st p\u0159\u00edsn\u011b randomizovanou studii.<\/p>\n\n\n\n

V\u011b\u0159\u00edme, \u017ee jste prost\u0159ednictv\u00edm tohoto blogu s citacemi z nov\u00e9 studie o u\u017e\u00edv\u00e1n\u00ed CBD p\u0159i COVID-19 z\u00edskali lep\u0161\u00ed p\u0159edstavu o \u00fa\u010dinc\u00edch CBD nejen na obt\u00ed\u017ee spojen\u00e9 s onemocn\u011bn\u00edm COVID-19. Pokud uva\u017eujete o k\u00fa\u0159e CBD, doporu\u010dujeme v\u00e1m p\u0159e\u010d\u00edst si v\u00edce o organick\u00fdch CBD olej\u00edch CBDium<\/a>, kter\u00e9 (mimo jin\u00e9) podporuj\u00ed zdrav\u00fd sp\u00e1nek, celkovou rovnov\u00e1hu pH, rovnov\u00e1hu v\u0161ech vnit\u0159n\u00edch syst\u00e9m\u016f t\u011bla, pom\u00e1haj\u00ed se stabilitou centr\u00e1ln\u00ed nervov\u00e9 soustavy nebo nastartuj\u00ed imunitu.<\/p>\n\n\n\n

Reference<\/h3>\n\n\n\n
    \n
  1. National Center for Biotechnology Information: Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response<\/a>.<\/li>\n\n\n\n
  2. Health Europa: Medicinal cannabis may play a significant role during COVID-19<\/a><\/li>\n\n\n\n
  3. WebMD: Coronavirus: what happens when you get infected?<\/a><\/li>\n\n\n\n
  4. C. Coetzee, R.-A. Levendal, M. van de Venter, C.L. Frost. Anticoagulant effects of a cannabis extract in an obese rat model. Phytomedicine 14 (2007) 333\u2013337.<\/li>\n\n\n\n
  5. Wang, B.; Kovalchuk, A.; Li, D.; Ilnytskyy, Y.; Kovalchuk, I.; Kovalchuk, O. In search of preventative strategies: novel anti-inflammatory high-CBD Cannabis Sativa extracts modulate ACE2 expression in COVID-19 gateway tissues. Preprints 2020, 2020040315 (doi: 10.20944\/preprints202004.0315.v1).<\/li>\n\n\n\n
  6. Mabou Tagne A, Pacchetti B, Sodergren M, et al. Cannabidiol for viral diseases: hype or hope? Cannabis Cannabinoid Res. 2020;5:121\u2013131.<\/li>\n\n\n\n
  7. InnoCan Pharma collaborates with Tel Aviv University to develop a new revolutionary approach to treat the COVID-19 coronavirus with exosomes-loaded CBD<\/a>.<\/li>\n\n\n\n
  8. Forbes: Compounds In Cannabis Show Promise As A Treatment For Coronavirus Infections<\/a>.<\/li>\n\n\n\n
  9. Startitup: Nov\u00e1 \u0161t\u00fadia uk\u00e1zala, \u017ee CBD m\u00f4\u017ee pom\u00f4c\u0165 zmierni\u0165 z\u00e1pal v p\u013e\u00facach pacientov s COVID-19<\/a>.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Rychl\u00e9 \u0161\u00ed\u0159en\u00ed COVID-19 a p\u0159ib\u00fdv\u00e1n\u00ed nov\u00fdch variant zd\u016fraz\u0148uje vzhledem k z\u00e1va\u017enosti situace pot\u0159ebu nov\u00fdch l\u00e9\u010debn\u00fdch postup\u016f. Na z\u00e1klad\u011b studie, kterou provedli v\u011bdci z University of Chicago na 85 neo\u010dkovan\u00fdch pacientech s COVID, jsme se dozv\u011bd\u011bli, \u017ee u\u017e\u00edv\u00e1n\u00edm CBD p\u0159i COVID-19 m\u016f\u017eeme potenci\u00e1ln\u011b \u0159e\u0161it p\u0159\u00edznaky tohoto virov\u00e9ho onemocn\u011bn\u00ed a p\u0159\u00edpadn\u011b zlep\u0161it prevenci. Endokanabinoidn\u00ed receptory  V t\u011ble […]<\/p>\n","protected":false},"author":16,"featured_media":27776,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[31],"tags":[],"class_list":["post-27566","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-cs"],"acf":[],"_links":{"self":[{"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/posts\/27566","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/comments?post=27566"}],"version-history":[{"count":3,"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/posts\/27566\/revisions"}],"predecessor-version":[{"id":29065,"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/posts\/27566\/revisions\/29065"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/media\/27776"}],"wp:attachment":[{"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/media?parent=27566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/categories?post=27566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cbdium.eu\/cs\/wp-json\/wp\/v2\/tags?post=27566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}